Irritant potential of one buccal spray of propolis and eucalyptus in oral mucous of hamster
Main Article Content
Abstract
The buccal spray made from Propomax 5 and eucalyptus essential oil is a valid and effective for the welfare of the throat and oral cavity help. In addition to creating a protective layer that prevents the entry of viruses, bacteria and fungal growth, also it has anti-inflammatory effect on the mucous membranes of pharynx, larynx and throat. It stimulates the generation of dentine and prevents cavities and plaque. This formula is a solution that we will be used for application to oral mucous. One of the risks of this job is the potential irritant that could express the product by its contact with the oral mucous. For the characterization of their toxicological potential acute irritant effects after administration of the oral mucous hamster, five batches of a mouth spray solution were determined, showing an irritant response null; so we concluded that this substance classified as "Nonirritating".
Article Details
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Those authors who have publications with this journal accept the following terms of the License Attribution-NonCommercial 4.0 International (CC BY-NC 4.0):
You are free to:
- Share — copy and redistribute the material in any medium or format
- Adapt — remix, transform, and build upon the material
The licensor cannot revoke these freedoms as long as you follow the license terms.
Under the following terms:
- Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
- NonCommercial — You may not use the material for commercial purposes.
- No additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.
The journal is not responsible for the opinions and concepts expressed in the works, they are the sole responsibility of the authors. The Editor, with the assistance of the Editorial Committee, reserves the right to suggest or request advisable or necessary modifications. They are accepted to publish original scientific papers, research results of interest that have not been published or sent to another journal for the same purpose.
The mention of trademarks of equipment, instruments or specific materials is for identification purposes, and there is no promotional commitment in relation to them, neither by the authors nor by the publisher.
How to Cite
References
Amoros, M., C. M. Simões, L. Girre, F. Sauvager, and M. Cormier. (1992). Synergistic effect of flavones and flavonols against herpes simplex virus type 1 in cell culture. Comparison with the antiviral activity of propolis. Journal of Natural Product. 55:17321740.
Bankova, V., R. Christov, A. Kujumgiev, M. C. Marcucci, and S. Popov. (1995). Chemical composition and antibacterial activity of Brazilian propolis. Z. Naturforsch. 50c:167-172.
Banskota, A. H., Y. Tezuka, J. K. Prasain, K. Matsushige, I. Saiki, and S. Kadota. (1998). Chemical constituents of Brazilian propolis and their cytotoxic activities. Journal of Natural Product. 61:896-900.
Bonhevì, J. S., F. V. Coll, and R. E. Jordà. (1994). The composition, active components and bacteriostatic activity of propolis in dietetics. Journal American Oil Chemestry. Soc. 71:529-532.
Burdock, G. A. (1998). Review of the biological properties and toxicity of propolis. Food Chem. Toxicol. 36:341-363.
Chan, P.K. and Hayes, A.W. (1994). Acute Toxicity and Eye Irritancy. In: Principles and Methods of Toxicology. Third Edition. A.W. Hayes, Editor. Raven Press Ltd., New York, USA, 54-58.
Duailibe SA, Gonçalves AG, Ahid FJ. (2007). Effect of a propolis extract on Streptococcus mutans counts in vivo. J. Appl Oral Sci. Oct; 15(5):420-3.
Eguizábal A., M. and Moromi Nakata, H. (2007). Actividad antibacteriana in vitro del extracto etanólico de propóleo peruano sobre Streptococcus mutans y Lactobacillus casei. Rev. Odontología Sanmarquina. 10(2).
FDA. 2012. Good laboratory practice (GLP) for non-clinical laboratory studies. 21 CFR Part. 58. Disponible en: http://www.fda.gov/ohrms/dockets/98fr/98033 5s1.pdf. [Consultado Jun. 5, 2015].
Ghisalberti, E. L. (1979). Propolis: a review. Bee World. 60:59-84.
Ikeno, K., T. Ikeno, and C. Miyazawa. (1991). Effects of propolis on dental caries in rats. Caries Res. 25:347–351.
Instituto Cubano de Normalización, Metrología y Control de la Calidad (ICNMCC). 1975. Control de la Calidad. Selección de muestras aleatorias. Tabla. NC-92-09. La Habana: ICNMCC, 1-14.
Koo, H., A. M. Vacca Smith, W. H. Bowen, P. L. Rosalen, J. A. Cury, and Y. K. Park. (2000). Effects of Apis mellifera propolis on the activities of streptococcal glucosyltransferases in solution and adsorbed onto saliva-coated hydroxyapatite. Caries Res. 34:361- 442.
Koo, H., B. P. F. A. Gomes, P. L. Rosalen, G. M. B. Ambrosano, Y. K. Park, and J. A. Cury. (2000). In vitro antimicrobial activity of propolis and Arnica montana against oral pathogens. Arch. Oral Biol. 45:141-148
Koo, H., P. L. Rosalen, J. A. Cury, G. M. B. Ambrosano, R. M. Murata, R. Yatsuda, M. Ikegaki, S. M. Alencar, and Y. K. Park. (2000). Effect of a new variety of Apis mellifera propolis on mutans streptococci. Curr. Microbiol. 41:192-196.
Koo, H., P. L. Rosalen, J. A. Cury, Y. K. Park, M. Ikegaki, and A. Sattler. (1999). Effect of Apis mellifera propolis from two Brazilian regions on caries development in desalivated rats. Caries Res. 33:393–400.
Koo, H.; Rosalen, P.; Cury, J.A.; Park, Y.K. and Bowen, W.H. (2002). Effects of Compounds Found in Propolis on Streptococcus mutans Growth and on Glucosyltransferase Activity. Antimicrob Agents Chemother. May; 46(5): 1302–1309.
Moreno, Z., Martínez, P.; Figueroa, J. (2007). Efecto antimicrobiano in vitro de propóleos argentinos, colombianos y cubano sobre Streptococcus mutans ATCC 25175. Rev. NOVA - Publicación Científica - ISSN: 1794-2470. 5(7):1-100.
Park, Y. K., M. H. Koo, J. A. S. Abreu, M. Ikegaki, J. A. Cury, and P. L. Rosalen. (1998). Antimicrobial activity of propolis on oral microorganisms. Curr. Microbiol. 36:24-28.
Premoli, G.; Laguado, P.; Díaz, N.; Romero, C.; Villarreal, J.; González, A.J. (2010). Uso del Propóleo en odontología. Acta Odontol. Venez; 48(2).
Propiedades medicinales del eucalipto. Disponible en: http://www.botanicalonline.com/medicinalseucalipto.htm. [Consultado Jun. 5, 2015].
Tazawa, S., T. Warashina, T. Noro, and T. Miyase. (1998). Studies on the constituents of Brazilian propolis. Chem. Pharm. Bull. 46:1477-1479.
UNE-EN ISO 10993-10, (2003). Evaluación Biológica de productos sanitarios. Parte 10: Ensayos de irritación e hipersensibilidad retardada. Norma española (ISO 1099310:2002): 35-39.